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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Caspase-1 is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta, interleukin 18, and interleukin 33 precursor proteins. The Caspase-1 gene consists of 10 exons spanning at least 10.6 kb and is mapped to 11q23, a site frequently involved in rearrangement in human cancers, including a number of leukemias and lymphomas.
Titration of the Caspase-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
An amino acid sequence from the N-terminus of human CASP1 (CSLEEAQRIWKQKSAEIY) was used as the immunogen for this Caspase-1 antibody. The sequence is from the large subunit.
The lyophilized Caspase-1 antibody can be stored at 4oC. After reconstitution, aliquot and store at -20oC. Repeated freeze/thaw steps should be avoided.
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