- Tel: 858.663.9055
- Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.
Titration of the CAD antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 780-809 from the human protein was used as the immunogen for this CAD antibody.
Aliquot the CAD antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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