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Home >> Antibodies >> CA8 Antibody / Carbonic Anhydrase VIII

CA8 Antibody / Carbonic Anhydrase VIII [clone rCA8/8835] (V5245)

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  Catalog No Formulation Size Price (USD)  
Image V5245-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V5245-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V5245SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recmousemono
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SDS-PAGE analysis of purified, BSA-free CA8 antibody (clone rCA8/8835) as confirmation of integrity and purity.
SDS-PAGE analysis of purified, BSA-free CA8 antibody (clone rCA8/8835) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Mouse Monoclonal
Isotype Mouse IgG1, kappa
Clone Name rCA8/8835
Purity Protein A/G affinity
UniProt P35219
Localization Cytoplasm, Cell surface
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This CA8 antibody is available for research use only.
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Description

The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in CA8 gene causes neuropathology, such as ataxia, mild mental retardation and the predisposition to quadrupedal gait. It is also associated with the development of colorectal and lung cancers. Additionally, it is upregulated in various cancers.

Application Notes

Optimal dilution of the CA8 antibody should be determined by the researcher.

Immunogen

Recombinant full-length human protein was used as the immunogen for the CA8 antibody.

Storage

Aliquot the CA8 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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