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Home >> Antibodies >> c-RET Antibody

c-RET Antibody [clone 188CT11.2.3] (F53523)

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  Catalog No Formulation Size Price (USD)  
Image F53523-0.1ML In ascites with 0.09% sodium azide 0.1 ml 399
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Western blot testing of human A549 cell lysate with c-RET antibody.
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Western blot testing of human A549 cell lysate with c-RET antibody.
c-RET antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue.
Confocal immunofluorescent analysis of c-RET antibody with MDA-MB231 cells followed by Alexa Fluor 488-conjugated goat anti-mouse lgG (green). Actin filaments have been labeled with Alexa Fluor 555 Phalloidin (red). DAPI was used as a nuclear counterstain (blue).
Western blot testing of mouse heart lysate with c-RET antibody.
Availability 1-3 business days
Species Reactivity Human
Format Ascites
Clonality Monoclonal (mouse origin)
Isotype Mouse IgM, k
Clone Name 188CT11.2.3
Purity Ascites
UniProt P07949
Applications Western blot : 1:500-1:16000
IHC (Paraffin) : 1:50-1:100
Immunofluorescence : 1:10-1:50
Limitations This c-RET antibody is available for research use only.
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Description

This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.

Application Notes

Titration of the c-RET antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

This c-RET antibody was raised using purified His-tagged recombinant human c-RET.

Storage

Aliquot the c-RET antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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