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Home >> Antibodies >> BRCA1 Antibody

BRCA1 Antibody [clone BRCA1/1398] (V3240)

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  Catalog No Formulation Size Price (USD)  
Image V3240-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V3240-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V3240SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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IHC testing of FFPE human breast carcinoma tissue with BRCA1 antibody (clone BRCA1/1398). HIER: boil tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min.
IHC testing of FFPE human breast carcinoma tissue with BRCA1 antibody (clone BRCA1/1398). HIER: boil tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name BRCA1/1398
Purity Protein G affinity chromatography
UniProt P38398
Localization Nuclear, cytoplasmic
Applications Immunohistochemistry (FFPE) : 2-5ug/ml for 60 min at RT
Limitations This BRCA1 antibody is available for research use only.
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Description

BRCA1 (Breast cancer type 1 susceptibility protein) is a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Application Notes

Optimal dilution of the BRCA1 antibody should be determined by the researcher.

Immunogen

Amino acids 445-620 were used as the immunogen for the BRCA1 antibody.

Storage

Store the BRCA1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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