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Home >> Antibodies >> BIRC5 Antibody / Survivin

BIRC5 Antibody / Survivin [clone ABB-2] (RQ4728)

  Catalog No Formulation Size Price (USD)  
Image RQ4728 Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA 100 ul 429
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IHC staining of FFPE human gastric carcinoma with BIRC5 antibody. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.
Western blot testing of human Jurkat cell lysate with BIRC5 antibody. Predicted molecular weight ~16 kDa.
Availability 1-2 weeks
Species Reactivity Human
Format Purified
Clonality Rabbit Monoclonal
Isotype Rabbit IgG
Clone Name ABB-2
Purity Affinity purified
UniProt O15392
Localization Nuclear, cytoplasmic
Applications Western blot : 1:500-1:2000
Immunohistochemistry (FFPE) : 1:50-1:200
Limitations This BIRC5 antibody is available for research use only.
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Description

The BIRC5 gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. [RefSeq]

Application Notes

Optimal dilution of the BIRC5 antibody should be determined by the researcher.

Immunogen

A synthetic peptide specific to human Survivin / BIRC5 was used as the immunogen for the BIRC5 antibody.

Storage

Store the BIRC5 antibody at -20oC.

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