- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Bcl10 Antibody [clone GDB-2] (RQ4824)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
RQ4824 | Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA | 100 ul | 429 |
|
| Availability | 1-2 weeks |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | GDB-2 |
| Purity | Affinity purified |
| UniProt | O95999 |
| Applications | Western blot : 1:1000-1:2000 |
| Limitations | This Bcl10 antibody is available for research use only. |
|
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Bcl10 contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. It is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. Bcl10 is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [RefSeq]
Optimal dilution of the Bcl10 antibody should be determined by the researcher.
A synthetic peptide specific to human Bcl10 was used as the immunogen for the Bcl10 antibody.
Store the Bcl10 antibody at -20oC.
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