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Home >> Antibodies >> Bcl-XL Antibody

Bcl-XL Antibody (R32762)

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  Catalog No Formulation Size Price (USD)  
Image R32762 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of 1) rat thymus, 2) mouse NIH3T3, 3) mouse Hepa1-6, 4) human SGC-7901 and 5) human HepG2 lysate with Bcl-XL antibody at 0.5ug/ml. Expected molecular weight: 26-30 kDa.
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Western blot testing of 1) rat thymus, 2) mouse NIH3T3, 3) mouse Hepa1-6, 4) human SGC-7901 and 5) human HepG2 lysate with Bcl-XL antibody at 0.5ug/ml. Expected molecular weight: 26-30 kDa.
IHC testing of FFPE human breast cancer tissue with Bcl-XL antibody at 1ug/ml. Required HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to testing.
IHC testing of FFPE human tonsil tissue with Bcl-XL antibody at 1ug/ml. Required HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to testing.
IHC testing of FFPE human lung cancer tissue with Bcl-XL antibody at 1ug/ml. Required HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to testing.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide
UniProt Q07817
Localization Cytoplasmic, membranous
Applications Western blot : 0.5-1ug/ml
Immunohistochemistry (FFPE) : 1-2ug/ml
Flow cytometry : 1-3ug/million cells
Limitations This Bcl-XL antibody is available for research use only.
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Description

Bcl-2-like protein 1, also known as Bcl-XL, is a protein that in humans is encoded by the BCL2L1 gene. The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform (Bcl-xL) acts as an apoptotic inhibitor and the shorter form (Bcl-xS) acts as an apoptotic activator.

Application Notes

Optimal dilution of the Bcl-XL antibody should be determined by the researcher.

Immunogen

Amino acids M1-T219 from the human protein were used as the immunogen for the Bcl-XL antibody.

Storage

After reconstitution, the Bcl-XL antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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