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- Email: info@nsjbio.com
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Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. [UniProt]
The stated application concentrations are suggested starting amounts. Titration of the BACE1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 38-70 from the human protein was used as the immunogen for this BACE1 antibody.
Store at 4oC for up to one month. For long term, aliquot the BACE1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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