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Home >> Antibodies >> ACTH Antibody Cocktail / Synacthen

ACTH Antibody Cocktail / Synacthen [clone AH26 + 57] (V3176)

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  Catalog No Formulation Size Price (USD)  
Image V3176-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V3176-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V3176SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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IHC: Formalin-fixed, paraffin-embedded human pituitary gland stained with ACTH antibody (AH26 + 57). Required HIER: boil tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
IHC: Formalin-fixed, paraffin-embedded human pituitary gland stained with ACTH antibody (AH26 + 57). Required HIER: boil tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1 + IgG1
Clone Name AH26 + 57
Purity Protein G affinity chromatography
UniProt P01189
Localization Cytoplasm
Applications Immunohistochemistry (FFPE) : 0.5-1ug/ml for 30 min at RT
Limitations This ACTH antibody cocktail is available for research use only.
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Description

ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This cocktail is specific to Synacthen (aa1-24 of ACTH); does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.

Application Notes

The optimal dilution of the ACTH antibody for each application should be determined by the researcher.

Immunogen

Amino acids 1-24 (AH26) and an N-terminal peptide from human ACTH (57) were used as the immunogens for this ACTH antibody cocktail.

Storage

Store the ACTH antibody cocktail at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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